β3-AR agonist 1
CAS No. : 1283125-73-4
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| Cat. No. : | HY-101514 |
| M.Wt: | 444.55 |
| Formula: | C22H28N4O4S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
β3-AR agonist 1 (compound 15) is a highly potent, selective, and orally available β3-adrenergic receptor (β3-AR) agonist (EC50=18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/β3, and α1A/β3>556-fold)[1]. IC50 & Target: EC50: 18 nM (β3-AR)[1] In Vivo: β3-AR agonist 1 (compound 15) shows dose-dependent β3-AR-mediated responses in marmoset urinary bladder smooth muscle, has a desirable metabolic stability and pharmacokinetic profile (Cmax and AUC), and do not obviously affect heart rate or mean blood pressure when administered intravenously (3 mg/kg) to anesthetized rats[1].
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