Ro 24-5913
CAS No. : 128312-51-6
(Synonyms: Cinalukast)
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| Cat. No. : | HY-107611 |
| M.Wt: | 412.55 |
| Formula: | C23H28N2O3S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Ro 24-5913 (Cinalukast) is an orally active and potent LTD4 antagonist with an IC50 value of 6.4 nM. Ro 24-5913 can be used for the research of asthma[1]. IC50 & Target:IC50: 6.4 nM (LTD4)[1] In Vitro:Ro 24-5913 competes with [3H]LTD4 for its binding site in guinea pig lung membranes with an IC50 value of 6.4 nM[1]. Ro 24-5913 shows effective antagonist efficacy to LTD4-induced contractions with a pKB value of 9.3[1]. In Vivo:Ro 24-5913 (10 mg/kg i.v. and 100 mg/kg p.o.; once) inhibits LTD4-induced bronchoconstriction in guinea pigs with LD50s of 0.13 and 0.12 mg/kg for i.v. and p.o. respectively[1].
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