(S)-PNU-282987 (hydrochloride)
CAS No. : 128311-08-0
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| Cat. No. : | HY-12560C |
| M.Wt: | 301.21 |
| Formula: | C14H18Cl2N2O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO;10 mM in DMSO |
(S)-PNU-282987 hydrochloride is an isoform of PNU-282987 (HY-12560). PNU-282987 (free base) is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC50 of 154 nM. PNU-282987 (free base) is also a functional antagonist of the 5-HT3 receptor with an IC50 of 4541 nM. PNU-282987 (free base) can be used for the research of central and peripheral nervous systems[1].
In Vitro:PNU-282987 (free base) (Compound C7) can replace the R7 selective antagonist methylaconitine (MLA) in rat brain homogenate with a Ki of 27 nM[1].
PNU-282987 has α7 nAChR agonist activity with an EC50 of 154 nM[1].
PNU-282987 also inhibits the 5-HT3 receptor with an IC50 value of 4541 nM[1].
In Vivo:PNU-282987 (free base) (Compound C7) (i.v.; 1, 3 mg/kg) leads to a reversal of the gating deficit[1].
PNU-282987 (30 μM) evokes currents in rat hippocampal neurons in a concentration-dependent and MLA blockable manner[1].
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