Bivalirudin
CAS No. : 128270-60-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $55 | In-stock |
| 10mg | $90 | In-stock |
| 25mg | $180 | In-stock |
| 50mg | $300 | In-stock |
| 100mg | $480 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-P1929 |
| M.Wt: | 2180.29 |
| Formula: | C98H138N24O33 |
| Purity: | >98 % |
| Solubility: | H2O : 10 mg/mL (ultrasonic) |
Bivalirudin, a hirudin analog and anticoagulant, is a direct thrombin inhibitor. Bivalirudin inhibits thrombin-mediated fibrinogen cleavage, coagulation factor activation, and platelet activation by reversibly binding to thrombin. In addition, Bivalirudin also has certain effects of anti-virus, anti-inflammation, and vascular endothelial barrier function protection. Bivalirudin can be used for the research of thrombotic diseases and others[1][2][3][4].
In Vitro: Bivalirudin (30 μg/mL; 10 min) inhibits Thrombin (HY-114164)-induced S1PR2 upregulation and endothelial hyperpermeability, and reverses the abnormal distribution of cytoskeletal proteins and β-catenin in HUVECs[1].
In Vivo: Bivalirudin (2 mg/kg; intravenous injection; every other day; 2 weeks) exhibits antiviral activity against respiratory syncytial virus in neonatal C57BL/6 mice[2].
Bivalirudin (2 mg/kg; intravenous injection; single dose) inhibits thrombosis in mice[3].
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