Escitalopram


CAS No. : 128196-01-0

(Synonyms: (S)-Citalopram; (S)-(+)-Citalopram)

128196-01-0
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Cat. No. : HY-14258
M.Wt: 324.39
Formula: C20H21FN2O
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic)
Introduction of 128196-01-0 :

Escitalopram ((S)-Citalopram), the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram is an antidepressant for the research of major depression[1][2]. IC50 & Target: Ki: 0.89 nM (serotonin transporter), 10500 nM (DAT), 8150 nM (NET)[1] In Vivo: Escitalopram (10 mg/kg; i.p.; daily for 28 days) ameliorates cognitive impairments and selectively attenuates phosphorylated tau accumulation in stressed rats[3].
Chronic administration of Escitalopram (daily; drinking water for a total of 4 months) significantly reduces plaque load by 28% and 34% at 2.5 and 5 mg/d, respectively [4].

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