Lys-SMCC-DM1
CAS No. : 1281816-04-3
(Synonyms: Lys-Nε-MCC-DM1)
| Size | Price | Stock |
|---|---|---|
| 1mg | $352 | In-stock |
| 5mg | $880 | In-stock |
| 10mg | $1300 | In-stock |
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| Cat. No. : | HY-101982 |
| M.Wt: | 1103.71 |
| Formula: | C53H75ClN6O15S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) is a agent-linker conjugates for ADC that can inhibit tubulin polymerization. Lys-SMCC-DM1 is the active metabolite of T-DM1. T-DM1 is a HER2-targeting ADC with a tubulin polymerization inhibitor DM1. Lys-SMCC-DM1 can be used in the research of breast cancer[1][2].
In Vitro: Lys-SMCC-DM1 possess a low level of permeability[1].
Lys-SMCC-DM1 shows cytotoxicity in KPL-4 and MDA-MB-468 cells, with IC50 of 24.8 nM and 40.5 nM respectively[2].
Lys-SMCC-DM1 (200 μM) inhibits the SLC46A3-mediated uptake of estrone 3-sulfate in MDCKII/SLC46A3 dC cells[2].
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