X-370


CAS No. : 1280725-80-5

1280725-80-5
Price and Availability of CAS No. : 1280725-80-5
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Cat. No. : HY-12482
M.Wt: 551.59
Formula: C27H31F2N9O2
Purity: >98 %
Solubility:
Introduction of 1280725-80-5 :

X-370 is a PI3Kδ inhibitor (IC50 = 7 nM). X-370 inhibits the survival of leukemia cells, inducing G1 arrest and apoptosis. X-370 blocks PDK1 binding and phosphorylation of MEK1/2, eliminating Akt and Erk1/2 signaling. X-370 can be used in research on B-cell acute lymphoblastic leukemia (B-ALL)[1].

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