Sennoside B
CAS No. : 128-57-4
| Size | Price | Stock |
|---|---|---|
| 10mg | $25 | In-stock |
| 25mg | $50 | In-stock |
| 50mg | $80 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-N0366 |
| M.Wt: | 862.74 |
| Formula: | C42H38O20 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Sennoside B is a potent and orally active platelet-derived growth factor (PDGF) inhibitor. Sennoside B inhibits cell proliferation and the expression of phosphorylation of PDGFR-β, STAT-5, AKT and ERK induced by PDGF-BB. Sennoside B shows gastroprotective activities. Sennoside B has the potential for the research of gastritis[1][2].
In Vitro:Sennoside B increases prostaglandin E2 (PGE2) levels and inhibits H+/K+-ATPase[1].
Sennoside B (50, 100 µM) increases the concentration of PGE2 to 105.4 pg/mL and 173.6 pg/mL in AGS gastric cells at doses of 50 μM and 100 μM, respectively[1].
Sennoside B (0, 10, 100, 1000 nM) decreases the expression of PDGF-BB-induced phosphorylation of PDGFR-β, STAT-5, AKT and ERK in a dose-dependent manner[2].
In Vivo:Sennoside B (100 mg/kg; p.o.) shows gastroprotective activities by reducing lesion indices in HCl•EtOH and Indomethacin (HY-14397) induces gastritis in rats[1].
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