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N-Ethylmaleimide


CAS No. : 128-53-0

(Synonyms: NEM)

128-53-0
Price and Availability of CAS No. : 128-53-0
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Cat. No. : HY-D0843
M.Wt: 125.13
Formula: C6H7NO2
Purity: >98 %
Solubility: DMSO : 50 mg/mL (ultrasonic);H2O : 50 mg/mL (ultrasonic);Ethanol : 12.5 mg/mL (ultrasonic)
Introduction of 128-53-0 :

N-Ethylmaleimide (NEM) derives from maleic acid, it can alkylates free sulfhydryl. N-Ethylmaleimide is an irreversible cysteine protease inhibitor. N-ethylmaleimide specific inhibits phosphate transport in mitochondria. N-Ethylmaleimide inhibits prolyl endopeptidase with an IC50 value of 6.3 μM. N-Ethylmaleimide can be used to modify cysteine residues in proteins and peptides[1][2][3]. IC50 & Target: IC50: 6.3 μM (prolyl endopeptidase)[2] In Vitro: N-Ethylmaleimide (20 μM;30 min) inhibits Akt Ser-473, Akt Thr-308 , p70S6K, ribosomal protein S6, 4E-BP1, eIF4E, BAD and FKHR-L1 phosphorylation[2].
N-Ethylmaleimide (20 μM;30 min) affects conversion of pro-caspase-3 in vascular smooth muscle cells[2].
N-Ethylmaleimide (20 μM;6 h) promotes vascular smooth muscle cells apoptosis[2].
N-Ethylmaleimide (20 μM;30 min) affects PP2A activity and ROS production in vascular smooth muscle cells[2]. In Vivo: N-Ethylmaleimide (10 mg/kg; i.h.) promotes the prevalence situation of mice with acute gastric ulcers[3].

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