Saccharin (sodium)
CAS No. : 128-44-9
| Size | Price | Stock |
|---|---|---|
| 25g | $23 | In-stock |
| 100g | $92 | In-stock |
| 500g | $283 | In-stock |
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| Cat. No. : | HY-B1390A |
| M.Wt: | 205.17 |
| Formula: | C7H4NNaO3S |
| Purity: | >98 % |
| Solubility: |
Saccharin sodium is an orally active, non-caloric artificial sweetener (NAS). Saccharin sodium has bacteriostatic and microbiome-modulating properties. Saccharin binds to and signals via specific taste receptors, not only in the oral cavity but also alongside the gastrointestinal tract. Saccharin has been reported to bind the human and rodent heteromeric guanine nucleotide-binding protein (G protein) coupled sweet taste receptors T1R2/T2R3 as well as the human bitter taste receptor T2R43 and T2R44. Saccharin can inhibit bacterial growth in vitro[1].
In Vitro:Saccharin (5 mM, 0-14 h) exhibits bacteriostatic effects on Staphylococcus aureus, Klebsiella pneumonia, and Pseudomonas aeruginosa[1].
In Vivo:Saccharin (supplemented in water, 35 d) depicts reduced levels of bacterial 16S rRNA in fecal samples of mouse model[1].
Saccharin (supplemented in water, 7 d) improves intestinal inflammation in acute experimental colitis C57BL/6J wt mice[1].
Saccharin (0.1 mg/mL, supplemented in water, 5 w) has a protective influence on chronic DSS-colitis in mice[1].
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