Dryocrassin ABBA
CAS No. : 12777-70-7
(Synonyms: Dryocrassin)
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| Cat. No. : | HY-N0530 |
| M.Wt: | 820.83 |
| Formula: | C43H48O16 |
| Purity: | >98 % |
| Solubility: | DMSO : 16.67 mg/mL (ultrasonic);10 mM in DMSO |
Dryocrassin ABBA (Dryocrassin) is an orally active phloroglucinol derivative that can be extracted from Phyllopteris officinalis. Dryocrassin ABBA has antitumor and antiviral activity. Dryocrassin ABBA induced apoptosis of human hepatocellular carcinoma cells through mitochondrial pathway mediated by Caspase[1][2].
In Vitro:Dryocrassin ABBA (Dryocrassin) inhibits the activity of S. aureus SrtA (sortase A) with an IC50 of 24.17 μM[2].
In Vivo:Dryocrassin ABBA (Dryocrassin) (0-33 mg/kg; i.g.; daily, 7 days from day 2 to day 8) exerts a significant dose-dependent antiviral effect in mice[1].
Dryocrassin ABBA (100 mg/kg; s.c.; every 12 h for 96 h) can reduce infection and prevent mice from contracting S. aureus pneumonia[3].
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