Verruculogen
CAS No. : 12771-72-1
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| 5mg | $780 | In-stock |
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| Cat. No. : | HY-N6688 |
| M.Wt: | 511.57 |
| Formula: | C27H33N3O7 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL |
Verruculogen is a tremorgenic mycotoxin and inhibitor of the M phase of the mammalian cell cycle. Verruculogen is produced by Penicillium and Aspergillus species. Verruculogen enhances the binding of ChTX to maxi-k channels with a K1/2 value of 170 nM. Verruculogen inhibits the amplitude of Ca2+-activated K+ currents. Verruculogen induces severe tremors in infected animals[1][2][3][4][5].
In Vitro:Verruculogen enhances ChTX binding to maxi-k channels, with a K1/2 value of 170 nM[2].
Verruculogen (1 μM) significantly inhibits the amplitude of Thymol (HY-N6810)-stimulated Ca2+-activated K+ current (IK(Ca)) in pituitary GH3 cells[4].
In Vivo:Verruculogen (0.41 mg/kg; i.p.; single dose) can induce tremor syndrome in male Wistar rats and male C57BL/6N mice, with more severe symptoms and high mortality in mice[5].
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