VU0409106
CAS No. : 1276617-62-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $85 | In-stock |
| 10mg | $135 | In-stock |
| 25mg | $270 | In-stock |
| 50mg | $435 | In-stock |
| 100mg | $695 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-110180 |
| M.Wt: | 330.34 |
| Formula: | C15H11FN4O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 2 mg/mL (ultrasonic;warming;heat to 60°C) |
VU0409106 is a potent and selective mGlu5 negative allosteric modulator (NAM) with an IC50 of 24 nM. VU0409106 shows anxiolytic effects in rat models in a concentration-dependent manner. VU0409106 also penetrates the blood-brain barrier (BBB)[1][2]. IC50 & Target: IC50: 22.3 µM (CYP3A4)[1]. In Vivo: VU0409106 (10 mg/kg; i.p.; once) penetrates the blood-brain barrier (BBB) and demonstrates good brain to plasma ratio that near unity[1].
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