YLF-466D
CAS No. : 1273323-67-3
(Synonyms: C24)
| Size | Price | Stock |
|---|---|---|
| 2mg | $128 | In-stock |
| 5mg | $180 | In-stock |
| 10mg | $270 | In-stock |
| 25mg | $486 | In-stock |
| 50mg | $720 | In-stock |
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| Cat. No. : | HY-15840 |
| M.Wt: | 465.93 |
| Formula: | C29H20ClNO3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
YLF-466D is a newly developed AMPK activator, which inhibits platelet aggregation. IC50 & Target: AMPK[1] In Vitro: The effect of YLF-466D on platelet AMPK and aggregation are examined to test whether YLF-466D can stimulate AMPK in platelets and thereby suppress aggregation. Platelet AMPK is activated by YLF-466D, which is confirmed with activation-dependent phosphorylation at Thr172. Consistent with this result, YLF-466D inhibits platelet aggregation induced by thrombin. Such inhibition is observed in the aggregation elicited by ADP and collagen as well as thrombin, indicating that the antiaggregatory effect of YLF-466D is not platelet-agonist specific but common, regardless of agonist type. All the effects on AMPK and aggregation are concentration-dependent with the highest efficacy at 150 μM. IC50 against thrombin-, ADP- and collagen-induced aggreation are approximately 84, 55 and 87 μM, respectively[1].
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