Zamifenacin (fumarate)
CAS No. : 127308-98-9
(Synonyms: UK-76654 (fumarate))
| Size | Price | Stock |
|---|---|---|
| 5mg | $100 | In-stock |
| 10mg | $150 | In-stock |
| 25mg | $280 | In-stock |
| 50mg | $450 | In-stock |
| 100mg | $680 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-107649 |
| M.Wt: | 531.60 |
| Formula: | C31H33NO7 |
| Purity: | >98 % |
| Solubility: | H2O : 1 mg/mL (ultrasonic;warming;heat to 60°C);DMSO : 100 mg/mL (ultrasonic) |
Zamifenacin fumarate (UK-76654 fumarate) is a potent gut-selective muscarinic M3 receptor antagonist. Zamifenacin significantly reduces colonic motility in irritable bowel syndrome[1].
IC50 & Target: Muscarinic M3 receptor[1]
In Vivo: Zamifenacin exhibits moderate oral bioavailability (mouse 26%, rat 64%, dog 100%) and Cmax (mouse 92, rat 905, dog 416 ng/mL) following oral administration (mouse 13.2, rat 20 and, dog 5 mg/kg)[2].
Zamifenacin exhibits terminal elimination half-lives (mouse 2.1, rat 6.0 and, dog 1.1 h) due to high plasma clearance (68, 35, and 39 mL/min/kg respectively combined with large volumes of distribution (12.5, 19.0, and 3.5 L/kg respectively) following intravenous administration (mouse 5.3, rat 5.0 and, dog 1.0 mg/kg)[2].
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