LY309887
CAS No. : 127228-54-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $384 | In-stock |
| 10mg | $620 | In-stock |
| 25mg | $1350 | In-stock |
| 50mg | $2200 | In-stock |
| 100mg | $3390 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-10818 |
| M.Wt: | 449.48 |
| Formula: | C19H23N5O6S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), with a Ki of 6.5 nM, and has antitumor activity. IC50 & Target: Ki: 6.5 nM (GARFT), 1.78 nM (Folate receptor α), 18.2 nM (Folate receptor β)[1] In Vitro: LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), with a Ki of 6.5 nM for human GARFT and also has high affinity at human folate receptor (FR)α and FRβ (Ki, 1.78 nM and 18.2 nM, respectively). LY309887 is signigicantly cytotoxic against the human leukemia cell line CCRF-CEM with IC50 of 9.9 nM[1]. In Vivo: LY309887 (3 mg/kg-100 mg/kg, i.p.) shows complete inhibition on the tumor growth in mice bearing C3H mammary cancer cells[1].
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