MI-3
CAS No. : 1271738-59-0
(Synonyms: Menin-MLL inhibitor 3)
| Size | Price | Stock |
|---|---|---|
| 5mg | $135 | In-stock |
| 10mg | $203 | In-stock |
| 25mg | $346 | In-stock |
| 50mg | $503 | In-stock |
| 100mg | $730 | In-stock |
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| Cat. No. : | HY-15223 |
| M.Wt: | 375.55 |
| Formula: | C18H25N5S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 8.33 mg/mL (ultrasonic) |
MI-3 (Menin-MLL inhibitor 3) is a potent and high affinity menin-MLL inhibitor with an IC50 of 648 nM and a Kd of 201 nM[1].
IC50 & Target: IC50: 648 nM (menin-MLL); Kd: 201 nM (menin-MLL)[1]
In Vitro: MI-3 (12.5-50 μM; HEK293 cells) treatment effectively inhibits the menin-MLL-AF9 interaction in human cells[1].
MI-3 (0-1.6 μM; 72 hours; KOPN-8 and MV4;11 cells) treatment shows an effective and dose-dependent growth inhibition in KOPN-8, MV4 and ME-1 cells[1].
MI-3 (12.5-50 μM; 48 hours; MV4;11 cells) treatment results in a substantial, and dose-dependent increase in Annexin V and AnnexinV/propidium iodide (PI) cells, demonstrating an increase in the number of cells undergoing apoptosis[1].
MI-3 (6.25-25 μM; 6 days; THP-1 cells) treatment results in substantially reduced expression of HOXA9 and MEIS1[1].
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