Amdiglurax
CAS No. : 1270138-40-3
(Synonyms: NSI-189)
| Size | Price | Stock |
|---|---|---|
| 5mg | $28 | In-stock |
| 10mg | $46 | In-stock |
| 25mg | $100 | In-stock |
| 50mg | $160 | In-stock |
| 100mg | $256 | In-stock |
| 200mg | $398 | In-stock |
| 500 mg | Get quote | |
| 1 g | Get quote | |
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| Cat. No. : | HY-13999 |
| M.Wt: | 366.50 |
| Formula: | C22H30N4O |
| Purity: | >98 % |
| Solubility: |
Amdiglurax (NSI-189) is an orally active chemical entity with enhanced neurogenic activity. Amdiglurax up-regulates neurogenic factors such as BDNF (brain derived-neurotrophic factor) and SCF. Amdiglurax exhibits anti-depressant effect. Amdiglurax enhances synaptic plasticity and reduces cognitive dysfunction. Amdiglurax holds potential for psychiatric disorder research[1][2][3].
In Vitro:Amdiglurax (NSI-189) enhances cell proliferation and neurogenesis in primary rat neurons (hippocampus) cells[2].
Amdiglurax significantly attenuates OGD (oxygen glucose deprivation) -mediated hippocampal cell death and increases Ki67 and MAP2 expression[2].
Amdiglurax up-regulates VEGF, GDNF, BDNF, SCF, BDNF and SCF levels in the hippocampal cells[2].
Amdiglurax (1.0-3.0 μM, 24 h) augments neurite outgrowth and mitochondrial function in adult rat DRG (Dorsal root ganglia) sensory neurons[3].
In Vivo:Amdiglurax (NSI-189) (30 mg/kg, p.o., at 6 h after stroke, daily, 12 weeks) promotes behavioral recovery in stroke model rats[2].
Amdiglurax (10 mg/kg, p.o., daily, 16 weeks) prevents PNS (peripheral nervous system) and CNS (central nervous system) neuropathy in type 1 diabetic mice[3].
Amdiglurax (30 mg/kg, p.o., daily, 26 weeks) prevents peripheral neuropathy and ameliorates CNS and PNS neuropathy indb/db mice[3].
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