Spadin
CAS No. : 1270083-24-3
| Size | Price | Stock |
|---|---|---|
| 1mg | $150 | In-stock |
| 5mg | $380 | In-stock |
| 10mg | $589 | In-stock |
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| Cat. No. : | HY-P1422 |
| M.Wt: | 2012.34 |
| Formula: | C96H142N26O22 |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 100 mg/mL |
Spadin, a natural peptide derived from a propeptide released in blood, is a potent TREK-1 channel blocker with IC50 value of 10 nM. Spadin enhances dorsal raphe nucleus 5-HT neurotransmission in mice and induces hippocampal CREB activation and neurogenesis. Spadin can be used for antidepressant research[1][2].
In Vitro: Spadin (100 nM; COS-7 cells) has inhibitory effect of spadin on the TREK-1 channel and blocks 63% of the TREK-1 current stimulated by arachidonic acid[1].
Spadin (100 nM) blocks the TREK-1 channels activity in CA3 hippocampal neurons on brain slices of wild-type mice[1].
In Vivo: Spadin (10 μM; i.p.; for 30 min; male C57Bl/6J and TREK-1 deficient mice) increases of the 5-HT neuron firing rate in the dorsal raphe nucleus (DRN)[2].
Spadin (0.01-100 μM; ICV, i.p. and i.v.; daily, for 7 days; male C57Bl/6J and TREK-1 deficient mice) has anti-depressant behavior in mice[2].
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