Sulfamerazine
CAS No. : 127-79-7
(Synonyms: RP2632)
| Size | Price | Stock |
|---|---|---|
| 500mg | $70 | In-stock |
| 1g | $120 | In-stock |
| 5g | $480 | In-stock |
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| Cat. No. : | HY-B0512 |
| M.Wt: | 264.30 |
| Formula: | C11H12N4O2S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL;H2O : < 0.1 mg/mL |
Sulfamerazine (RP2632) is a brain-penetrant and orally active sulfonamide antibiotic and α-synuclein inhibitor with human α-synuclein KD of 352 μM. Sulfamerazine inhibits the synthesis of dihydrofolate by bacteria, thereby inhibiting bacterial growth. Sulfamerazine inhibits α-synuclein fibrillation, reduces α-synuclein aggregation-associated toxicity and α-synuclein aggregate accumulation. Sulfamerazine can be used for the research of Parkinson’s disease and bacterial infection[1][2].
IC50 & Target:Antibacterial
In Vitro:Sulfamerazine (5-25 μM) reproducibly inhibits α-Syn fibrillation[1].
Sulfamerazine (0.31 μM; 24 h) reduces the accumulation of α-Syn aggregates in neuronal SH-SY5Y cells[1].
Sulfamerazine (25-200 μM; 24-48 h) is nontoxic to human neuroblastoma SH-SY5Y cells at concentrations up to 100 μM over 24-48 h, with reduced viability observed only at 200 μM[1].
Sulfamerazine (25-100 μM) exhibits a significant reduction in α-Syn aggregation and associated toxicity in Caenorhabditis elegans model of PD[1].
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