Sulfamerazine (sodium)
CAS No. : 127-58-2
(Synonyms: RP2632 (sodium))
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| Cat. No. : | HY-B0512A |
| M.Wt: | 286.29 |
| Formula: | C11H11N4NaO2S |
| Purity: | >98 % |
| Solubility: | 10 mM in H2O |
Sulfamerazine (RP2632) sodium salt is a brain-penetrant and orally active sulfonamide antibiotic and α-synuclein inhibitor with human α-synuclein KD of 352 μM. Sulfamerazine sodium salt inhibits the synthesis of dihydrofolate by bacteria, thereby inhibiting bacterial growth. Sulfamerazine sodium salt inhibits α-synuclein fibrillation, reduces α-synuclein aggregation-associated toxicity and α-synuclein aggregate accumulation. Sulfamerazine sodium salt can be used for the research of Parkinson’s disease and bacterial infection[1][2].
In Vitro:Sulfamerazine (5-25 μM) reproducibly inhibits α-Syn fibrillation[1].
Sulfamerazine (25-100 μM) exhibits a significant reduction in α-Syn aggregation and associated toxicity in Caenorhabditis elegans model of PD[1].
Sulfamerazine (0.31 μM; 24 h) reduces the accumulation of α-Syn aggregates in neuronal SH-SY5Y cells[1].
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