Trimethadione
CAS No. : 127-48-0
(Synonyms: 3,5,5,-Trimethyloxazolidine-2,4-dione)
| Size | Price | Stock |
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| 100mg | $56 | In-stock |
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| Cat. No. : | HY-A0092 |
| M.Wt: | 143.14 |
| Formula: | C6H9NO3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Trimethadione (3,5,5,-Trimethyloxazolidine-2,4-dione) is an oxazolidinedione anticonvulsant agent widely used against absences seizures. Trimethadione also is a T-type calcium channel blocker which has antihyperalgesic effects[1][2].
In Vivo:Trimethadione (100-600 mg/kg, ip, single dose) ameliorates Capsaicin (HY-10448)-induced mechanical hyperalgesia in rats, exhibits anticonvulsant effect in rat pentylenetetrazol-induced epilepsy model[2].
Trimethadione (200 mg/kg/day, po, in drinking water for 2-3 weeks) prevents and reduces the permanent hearing loss (PTS) induced by noise, ameliorates the temporary hearing loss (TTS) in C57BL/6J mouse models[3].
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