Demeclocycline
CAS No. : 127-33-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $110 | In-stock |
| 10mg | $180 | In-stock |
| 25mg | $360 | In-stock |
| 50mg | $580 | In-stock |
| 100mg | $920 | In-stock |
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| Cat. No. : | HY-121268 |
| M.Wt: | 464.85 |
| Formula: | C21H21ClN2O8 |
| Purity: | >98 % |
| Solubility: | H2O : 40 mg/mL (ultrasonic);DMSO : 25 mg/mL (ultrasonic) |
Demeclocycline is an orally active tetracycline antibiotic. Demeclocycline impairs protein synthesis by binding to the 30S ribosomal subunit to inhibit binding of aminoacyl tRNA. Demeclocycline shows anti-bacterial activitise to a wide variety of bacterial infections[1][2].
In Vitro:Demeclocycline (0-100 μM; 24 h) treatment reduces AQP2 abundance in mpkCCD cells[3].
Demeclocycline (10 μM; 24 h) treatment promotes the activity of monocytes and macrophages[4].
Demeclocycline (1-10 μM; 72 h) treatment directly affects the growth of brain tumorinitiating cells[4].
In Vivo:Demeclocycline (Intraperitoneal injection; 40 mg/kg; once daily; 48 h) treatment results in a significant reduction of hyponatremia and a significant correction of the hypoosmolality, and is not nephrotoxic[3].
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