CDK-IN-2


CAS No. : 1269815-17-9

(Synonyms: CDK inhibitor II)

1269815-17-9
Price and Availability of CAS No. : 1269815-17-9
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2mg $105 In-stock
5mg $190 In-stock
10mg $304 In-stock
25mg $578 In-stock
50mg $890 In-stock
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Cat. No. : HY-13033
M.Wt: 363.81
Formula: C18H19ClFN3O2
Purity: >98 %
Solubility: DMSO : ≥ 100 mg/mL
Introduction of 1269815-17-9 :

CDK-IN-2 is a specific CDK9 inhibitor with an IC50 of less than 8 nM. CDK-IN-2 reduces the phosphorylation level of H3S10. CDK-IN-2 decreases the transition rate of spermatocytes from prophase to metaphase I[1][2]. In Vitro:CDK-IN-2 (5.9 μM; 12 h) significantly reduces the proportion of spermatocytes transitioning from prophase to metaphase I in mouse primary spermatocytes (58.3% vs 96.4% in the control group) and reduces the phosphorylation level of the meiotic metaphase marker H3S10[2].

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