Encorafenib
CAS No. : 1269440-17-6
(Synonyms: LGX818)
| Size | Price | Stock |
|---|---|---|
| 1mg | $58 | In-stock |
| 5mg | $104 | In-stock |
| 10mg | $150 | In-stock |
| 25mg | $250 | In-stock |
| 50mg | $450 | In-stock |
| 100mg | $750 | In-stock |
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| Cat. No. : | HY-15605 |
| M.Wt: | 540.01 |
| Formula: | C22H27ClFN7O4S |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
Encorafenib (LGX818) is a highly potent BRAF inhibitor with selective anti-proliferative and apoptotic activity in cells expressing BRAFV600E (EC50=4 nM). IC50 & Target: IC50: 0.3 nM (BRafV600E) In Vitro: Encorafenib (LGX818) is a potent drug that can prevents diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf[1]. Encorafenib (LGX818) (10 nM) suppresses the ERK/MAPK pathway and displays marked inhibition of pERK in A375, G361 and SK-MEL-24 cells. 10 nM Encorafenib (LGX818) treatment for 12 days potently inhibits colony formation in A375, G361 and SK-MEL-24 cells, but not in RPMI7951 and C8161 cells. Encorafenib (LGX818) treatment induces a steady increase in the β-catenin level in G361 cells over time[2].
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