TL8-506 (GMP)
CAS No. : 1268163-15-0
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| Cat. No. : | HY-20457G |
| M.Wt: | 331.37 |
| Formula: | C20H17N3O2 |
| Purity: | >98 % |
| Solubility: |
TL8-506 (GMP) is TL8-506 (HY-20457) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. TL8-506 is a specific TLR8 agonist with an EC50 of 30 nM. TL8-506 has immunomodulatory effects and can be used in the study of tuberculosis and cancer immunotherapy[1][2].
In Vitro:TL8-506 (1 μM; 18 h) can activate dendritic cells in blood and tumors, induce the secretion of pro-inflammatory cytokines and chemokines, and promote the activation and recruitment of T cells (TL8-506 synergized with IFN-γ or Poly(I:C))[1].
TL8-506 can specifically activate TLR8 in vitro in TLR8 transgenic mouse bone marrow cells[2].
In Vivo:TL8-506 (intramuscular injection; twice; four weeks apart) can enhance the resistance to mycobacterium tuberculosis infection in TLR8 transgenic mice(TL8-506 and ESAT-6, aluminum hydroxide vaccine)[2].
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