DW532
CAS No. : 1267949-42-7
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| Cat. No. : | HY-116068 |
| M.Wt: | 300.27 |
| Formula: | C16H12O6 |
| Purity: | >98 % |
| Solubility: |
DW532 is a dual inhibitor of tubulin and tyrosine kinase, with IC50 values of 4.9 μM and 5.5 μM against EGFR and VEGFR2, respectively, and a KD of 3.6 μM for tubulin. DW532 induces cell cycle arrest at the G2/M phase, triggers cell apoptosis via caspase-related pathways, and inhibits angiogenesis. DW532 can be used for research related to cancers (e.g., breast cancer)[1].
In Vitro:DW532 (1-10 μM; 2 h) dose-dependently inhibits ligand-induced VEGFR2 activation and its downstream signaling pathways in HUVECs, as well as EGFR activation and its downstream signaling pathways in A431 human epithelial cancer cells[1].
DW532 (10-40 μM; 30 min) is a microtubule destabilizer that inhibits tubulin polymerization in vitro in a dose-dependent manner[1].
DW532 (0.1-10 μM; 12 h) dose-dependently inhibits tubulin polymerization in human breast cancer MDA-MB-468 cells, reduces the level of polymerized tubulin and increases the level of soluble tubulin[1].
DW532 (10 μM; 6 h) disrupts the microtubule network in human lung cancer A549 cells and induces diffuse tubulin staining, which is consistent with the characteristics of microtubule destabilization[1].
DW532 (72 h) potently and non-selectively inhibits the proliferation of a panel of 16 human cancer cell lines, with a mean IC50 of 1.82 μM[1].
DW532 (0.1-10 μM; 6 h) dose-dependently inhibits tube formation in human umbilical vein endothelial cells (HUVECs) in vitro[1].
DW532 (10 μM; 12 h) disrupts mitotic spindle assembly in human lung cancer A549 cells, induces chromosome dispersion and multipolar spindle formation, and rarely causes the appearance of monopolar spindles[1].
DW532 (1-10 μM; 24 h) induces G2/M phase arrest in MDA-MB-468, A549, PC-3, KB, K562 and A431 human cancer cells, accompanied by altered levels of mitosis-related proteins cyclin B1, p-CDK1 and p-H3[1].
DW532 (0.1-20 μM; 48 h) induces dose-dependent apoptosis in KB, MDA-MB-468 and A431 human cancer cells via a caspase-related mechanism[1].
In Vivo:DW532 (0.1-1 nmol per egg; local application) potently inhibits in vivo angiogenesis in the chick chorioallantoic membrane model[1].
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