Dihydroeponemycin


CAS No. : 126463-64-7

126463-64-7
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Cat. No. : HY-108553
M.Wt: 400.51
Formula: C20H36N2O6
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 126463-64-7 :

Dihydroeponemycin, an analogue of the antitumor and antiangiogenic natural product eponemycin, selectively targets the 20S proteasome. Dihydroeponemycin covalently modifies a subset of catalytic proteasomal subunits, binding preferentially to the IFN-gamma-inducible subunits LMP2 and LMP7. Dihydroeponemycin-mediated proteasome inhibition induces a spindle-like cellular morphological change and apoptosis[1].

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