Apomine
CAS No. : 126411-13-0
(Synonyms: SR-45023A; SR 9223i; SK&F-99085)
| Size | Price | Stock |
|---|---|---|
| 5mg | $340 | In-stock |
| 10mg | $490 | In-stock |
| 25mg | $795 | In-stock |
| 50mg | $1110 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-19671 |
| M.Wt: | 562.66 |
| Formula: | C28H52O7P2 |
| Purity: | >98 % |
| Solubility: | DMSO : 20 mg/mL (ultrasonic;warming;heat to 60°C) |
Apomine (SR-45023A) is an orally active antineoplastic agent that inhibits the mevalonate/isoprenoid pathway in cholesterol synthesis. Apomine can accelerate the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR). Apomine can also inhibit the growth of various types of cancer cells, including lung cancer, colon cancer, breast cancer, and skin cancer. Apomine is able to induce apoptosis in tumor cell lines derived from leukemia, colon cancer, liver cancer, ovarian cancer, and breast cancer[1][2].
In Vitro:Apomine (1-20 μM; 72 h) induces a dose-dependent increase in apoptosis in NCI H929, RPMI 8226 and JJN-3 human myeloma cells[2].
In Vivo:Apomine (200 mg/kg in the food; for 4 weeks) inhibits the development of multiple myeloma and lytic bone disease in mice[2].
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