BMS-932481
CAS No. : 1263871-36-8
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| Cat. No. : | HY-117957 |
| M.Wt: | 445.49 |
| Formula: | C24H24FN7O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
BMS-932481 is an orally active modulator for γ-secretase, selectively reduce Aβ1-42 and Aβ1-40 production, with IC50s of 6.6 and 25.3 nM, respectively[1].
In Vivo:BMS-932481 (2-30 mg/kg, po, single dose) reduces the levels of Aβ1-42 and Aβ1-40, increases levels of Aβ1-38 and Aβ1-37, without changing overall amounts of Aβ peptides in dog models[1].
BMS-932481 (2.5-15 mg/kg, iv, single dose) exhibits moderate brain penetration with brain-to-plasma ratio and AUCbrain to AUCplasma ratio of about 0.23 and 0.6 in Sprague-Dawley rats[1].
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