Lisavanbulin
CAS No. : 1263384-43-5
(Synonyms: BAL-101553)
| Size | Price | Stock |
|---|---|---|
| 5mg | $230 | In-stock |
| 10mg | $330 | In-stock |
| 25mg | $660 | In-stock |
| 50mg | $1055 | In-stock |
| 100mg | $1688 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-19916 |
| M.Wt: | 515.57 |
| Formula: | C26H29N9O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Lisavanbulin (BAL-101553) is the prodrug of the microtubule targeting agent Avanbulin (BAL 27862) (HY-106008). Lisavanbulin is a BBB-penetrant and orally active antitumor agent, especially in tumors that express high levels of end-binding protein 1. Lisavanbulin has ability to target tumor cell proliferation and affects the tumor microenvironment by reducing tumor microvasculature. Lisavanbulin is also a spindle assembly checkpoint activator. Lisavanbulin induces cell cycle arrest and subsequent death or aberrant chromosome segregation. Lisavanbulin can be studied in research for diffuse large B cell lymphoma (DLBCL) and glioblastoma[1][2][3][4].
In Vitro:Lisavanbulin (0-50 nM) has a cytostatic and cytolytic effect on SB28 cells with an IC50 of 5.5 nM[4].
Lisavanbulin (0-10 nM) increases the extracellular release of high mobility group box (HMGB1) in SB28 cells[4].
In Vivo:Lisavanbulin (25 mg/kg, p.o., 25 d) shows a clear reduction in tumor size in SB28 glioma implanted orthotopic C57BL/6J mice[4].
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