Etelcalcetide
CAS No. : 1262780-97-1
(Synonyms: Velcalcetide; AMG 416; KAI-4169)
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| Cat. No. : | HY-P1955 |
| M.Wt: | 1048.25 |
| Formula: | C38H73N21O10S2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Etelcalcetide (AMG 416; KAI-4169) is a synthetic calcimimetic as an activator of the calcium sensing receptor (CaSR). Etelcalcetide is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis, which is promising for research in the field of secondary hyperparathyroidism and chronic kidney disease[1][2]. In Vitro: Etelcalcetide hydrochloride (0-100 µmol/L, 2 h) dose-dependently reduces parathyroid hormone (PTH) levels in human parathyroid cells[2]. In Vivo: Etelcalcetide hydrochloride (2.5 µg/h and 20 µg/h, infusion, 3 days) significantly reduces plasma PTH concentrations and decreased the renal expression of Cyp24a1 with a higher delivery rate[1].
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