KHS101
CAS No. : 1262770-73-9
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| Cat. No. : | HY-10996 |
| M.Wt: | 339.46 |
| Formula: | C18H21N5S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
KHS101 is a small molecule that accelerates neuronal differentiation. KHS101 can distributes to the brain and resulted in a significant increase in neuronal differentiation[1].
In Vitro:KHS101 induces neuronal differentiation of adherently cultured rat NPCs in a dose-dependent fashion (EC50 ∼ 1 μM)[1].
KHS101 (5 μM) suppresses astrocyte formation in cultured NPCs[1].
KHS101 (5 μM; 24-72 h) negatively affects cell cycle progression and proliferation of NPCs[1].
KHS101 specifically interacts with TACC3 protein[1].
KHS101 (0–15 μM; 24 h) regulates the nuclear localization of the transcription factor ARNT2[1].
In Vivo:KHS101 (6 mg/kg; s.c.; BID for 14 days) distributes to the brain and significantly increases neuronal differentiation in rats in vivo[1].
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