Ginsenoside Rg4
CAS No. : 126223-28-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $390 | In-stock |
| 10mg | $630 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-N6580 |
| M.Wt: | 767.00 |
| Formula: | C42H70O12 |
| Purity: | >98 % |
| Solubility: | DMSO : 5 mg/mL (ultrasonic) |
Ginsenoside Rg4 is an orally active protopanaxatriol type ginsenoside. Ginsenoside Rg4 can activate PI3K, AKT and GSK-3β signaling. Ginsenoside Rg4 can inhibit ROS and inflammatory cytokine levels. Ginsenoside Rg4 can be used for the researches of inflammation, infection and metabolic disease, such as sepsis and lung inflammation[1][2][3].
In Vitro:Ginsenoside Rg4 (0.01-0.2 mg/mL, 6 h) decreases the expressions of toll-like receptor (TLR) 4 and TNF-α levels in HMGB1-activated HUVECs[1].
Ginsenoside Rg4 (0.1-0.2 mg/mL, 6 h) increases cell viability by activating PI3K/AKT signaling in HMGB1-activated HUVECs[1].
Ginsenoside Rg4 (20-50 μg/mL, 48 h) promotes the hair-inductive properties of DP cells by activating the AKT/GSK3β/β-catenin signaling pathway in dermal papilla (DP) sphere[2].
In Vivo:Ginsenoside Rg4 (10-15 mg/kg, i.v., 24 h after CLP) inhibits inflammation and prolongs survival in cecal ligation and puncture (CLP)-induced sepsis mice models[1].
Ginsenoside Rg4 (1-15 mg/kg, p.o., for 10 days) attenuates inflammation in PM2.5-induced pulmonary inflammation mice models[3].
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