Remikiren
CAS No. : 126222-34-2
(Synonyms: Ro 42-5892; Ro 42-5892/001)
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| Cat. No. : | HY-A0184 |
| M.Wt: | 630.84 |
| Formula: | C33H50N4O6S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Remikiren (Ro 42-5892) is an orally active and highly specific renin inhibitor. Remikiren specifically inhibits human reninand human plasma renin with IC50 values of 0.7 and 0.8 nM, respectively. Remikiren also reduces mean arterial blood pressure in sodium-depleted marmosets and squirrel monkeys. Remikiren can be used in study of hypertension[1].
IC50 & Target:IC50:0.7 nM (human pure renin), 0.8 nM (plasma renin of human)[1].
In Vitro:Remikiren (0-10 nM; 1-3 h) displays a considerable specificity to inhibit renin[1].
In Vivo:Remikiren (0.1, 0.3, 1, 3, 10 mg/kg; p.o.; single) reduces mean arterial blood pressure in a dose-dependent manner in sodium-depleted marmosets and squirrel monkeys[1].
Remikiren (3 mg/kg; p.o.; single) shows the duration of blood pressure decrease more than 24 h in sodium-depleted marmosets[1].
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