B-355252
CAS No. : 1261576-81-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $89 | In-stock |
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| Cat. No. : | HY-120553 |
| M.Wt: | 514.06 |
| Formula: | C25H24ClN3O3S2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
B355252, a phenoxy thiophene sulfonamide small molecule, is a potent NGF receptor agonist. B355252 potentiates NGF-induced neurite outgrowth. B355252 protects ischemic neurons from neuronal loss by attenuating DNA damage, reducing ROS production and the LDH level, and preventing neuronal apoptosis. B355252 has anti-apoptotic effects in glutamate-induced excitotoxicity, as well as in a murine hippocampal cell line (HT22) model of Parkinson disease (PD)[1]. In Vivo: B-355252 (0.125 mg/kg; ip; daily; 3 days) significantly attenuates the infarct volume and protects post-stroke neuronal loss in adult male Sprague–Dawley rats with cerebral ischemia[1].
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