GNF179
CAS No. : 1261114-01-5
| Size | Price | Stock |
|---|---|---|
| 1mg | $140 | In-stock |
| 5mg | $350 | In-stock |
| 10mg | $580 | In-stock |
| 25mg | $976 | In-stock |
| 50mg | $1296 | In-stock |
| 100mg | $1776 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-15975 |
| M.Wt: | 427.90 |
| Formula: | C22H23ClFN5O |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
GNF179 is an optimized 8,8-dimethyl imidazolopiperazine analog that exhibits antimalarial potency (IC50 of 4.8 nM against the multidrug resistant strain W2). GNF179 is orally active[1].
In Vitro:GNF179 does not rapidly inhibit parasite protein biosynthesis nor is it likely to target parasite cytochrome bc1, which has been validated as a hepatic stage target for Atovaquone (HY-13832). GNF179 may act against sporozoites instead of hepatic stages[1].
GNF179 (5-100 nM; 48 h) shows high inhibition of gametocyte sexual life cycle progression in the mosquito as it abolished oocyst formation at 5 nM[2].
In Vivo:GNF179 (15 mg/kg; p.o.; single dose) shows antimalarial activity in rodent malaria model[1].
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