Ganaplacide
CAS No. : 1261113-96-5
(Synonyms: KAF156; GNF156)
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| Cat. No. : | HY-108024 |
| M.Wt: | 411.45 |
| Formula: | C22H23F2N5O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO;10 mM in DMSO |
Ganaplacide (KAF156) is a first-in-class, orally active imidazolopiperazine antimalarial agent. Ganaplacide is active against a broad range of Plasmodium species, including drug-resistant parasites. Ganaplacide is parasiticidal against both asexual and sexual blood stages as well as the liver stages of the parasite[1][2].
In Vitro:Ganaplacide (KAF156) 对恶性疟原虫药物敏感和耐药菌株具有杀血裂殖活性，50% 抑制浓度为 6 至 17.4 nM[1]。
In Vivo:Ganaplacide (KAF156) displays cidal activity against mature Plasmodium falciparum gametocytes and thus blocks parasite transmission to Anopheles mosquitoes[1].
Ganaplacide (KAF156) (1-15 mg/kg; p.o.) is fully protective in a causal prophylactic mouse model of malaria[1].
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