FR 113680
CAS No. : 126088-92-4
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| Cat. No. : | HY-105436 |
| M.Wt: | 625.71 |
| Formula: | C35H39N5O6 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
FR 113680 is a tripeptide substance P antagonist that interacts selectively with the NK1 neurokinin receptor[1].
In Vitro:The inhibitory effect of FR 113680 on SP-induced guinea-pig ileum contraction is competitive and the pA2 value is 7.53[1].
FR 113680 has not effect on [3H]-SP binding to rat cerebral cortical membranes (NK1), [3H]-neurokinin A ([3H]-NKA) binding to rat duodenum smooth muscle membranes (NK2) and [3H]-eledoisin (Ele) binding to rat cerebral cortical membranes (NK3)[1].
In Vivo:FR 113680 (32 mg/kg; i.v.; once) significantly inhibits cigarette smoke-induced plasma extravasation[2].
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