LLL12
CAS No. : 1260247-42-4
| Size | Price | Stock |
|---|---|---|
| 1mg | $120 | In-stock |
| 5mg | $350 | In-stock |
| 10mg | $580 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-19536 |
| M.Wt: | 303.29 |
| Formula: | C14H9NO5S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C) |
LLL12 is a small molecule inhibitor of STAT3 that inhibits STAT3 phosphorylation. LLL12 enhanced the inhibitory effect of Cisplatin (HY-17394) and Paclitaxel (HY-B0015) on ovarian cancer cell formation, migration, and growth[1].
In Vitro: LLL12 (0.01-1 μM; 72 h) inhibits cell viability of ovarian cancer cell lines with or without Cisplatin (0.5 μM, 2.5 μM) and Paclitaxel (0.25 μM, 0.5 μM).[1].
LLL12 (0.25-1.0 μM; 72 h) inhibit STAT3 phosphorylation (Tyr705) in ovarian cancer cell lines[1].
In Vivo: LLL12 (5 mg/kg; i.p.; once daily for 13 d) shows strong growth inhibition activity in mouse osteosarcoma cells and tumor growth[2].
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