28-Deoxonimbolide
CAS No. : 126005-94-5
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| Cat. No. : | HY-N1710 |
| M.Wt: | 452.54 |
| Formula: | C27H32O6 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
28-Deoxonimbolide is a nimbin (HY-N3187) type limonoid, that can be isolated from Azadirachta indica seed extracts. 28-Deoxonimbolide shows anticancer activity. 28-Deoxonimbolide induces apoptotic cell death in HL60 cells via both the mitochondrial- and the death receptor-mediated pathways[1].
In Vitro:28-Deoxonimbolide (1-100 μM, 48 h) exhibits potent cytotoxic activity against HL60 (leukemia), A549 (lung), AZ521 (stomach), SK-BR-3 (breast), CRL1579 (melanoma), and RPMI1788 (normal lymphocyte) cells[1].
28-Deoxonimbolide (30 μM, 0-24 h) induces apoptosis in HL60 cells[1].
28-Deoxonimbolide (30 μM, 0-24 h) increases the levels of cleaved caspases-8, -9, and -3[1].
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