Polygalic acid
CAS No. : 1260-04-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $43 | In-stock |
| 10mg | $65 | In-stock |
| 25mg | $131 | In-stock |
| 50mg | $196 | In-stock |
| 100mg | $295 | In-stock |
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| Cat. No. : | HY-N1479 |
| M.Wt: | 488.66 |
| Formula: | C29H44O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Polygalic acid is a polyphenolic acid with neuroprotective effects, and also an inhibitor of African swine fever virus polymerase (AsfvPolX), with an IC50 value of 5.05 μM. Polygalic acid alleviates neuroinflammation by regulating cholinergic activity, and its fecal level decreases in diseased mice. Polygalic acid can be used in research related to painful diabetic peripheral neuropathy complicated with cognitive impairment and African swine fever[1][2]. In Vitro:Polygalic acid (25-200 μM; 24 h) is non-cytotoxic to PK-15 porcine kidney cells[2]. In Vivo:Polygalic acid negatively mediates the effect of Muribaculaceae (ASV243) on cognitive function in db/db mice with comorbid painful diabetic peripheral neuropathy and cognitive impairment, as well as the effect of Ruminococcus (ASV149) on thermal pain sensitivity in such mice[1].
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