L-Linalool

L-Linalool ((-)-Linalool) is a naturally derived monoterpene alcohol with oral activity, possessing neuroprotective, anti-inflammatory, and antioxidant activities. L-Linalool is a 5-HT₃ receptor inhibitor and a benzodiazepine-responsive GABA_A receptor enhancer. L-Linalool reduces nitrite and lipid peroxidation in the brain and partially prevents the decrease of striatal dopamine, DOPAC, and HVA. L-Linalool exhibits neuroprotective effects in hemiparkinsonian rats, cortical oxygen-glucose deprivation injury, and Alzheimer's disease models. L-Linalool prevents the decrease in tyrosine hydroxylase and dopamine transporter expression. L-Linalool can be used in research related to diseases such as Parkinson's disease and Alzheimer's disease^[1]. In Vitro:L-Linalool is a natural acyclic monoterpene alcohol that exists as two enantiomers, 3R-(-)-Linalool and 3S-(+)-Linalool^[1]. In Vivo:L-Linalool (LIN) (25-100 mg/kg; p.o.; daily; 15 days) is neuroprotective in 6-OHDA-lesioned hemiparkinsonian Wistar rats, improving behavioral deficits and partially preserving striatal dopamine, DOPAC, HVA, TH, and DAT while reducing nitrite and lipoperoxidation^[1].