Funapide
CAS No. : 1259933-16-8
(Synonyms: TV 45070; XEN402)
| Size | Price | Stock |
|---|---|---|
| 5mg | $390 | In-stock |
| 10mg | $590 | In-stock |
| 25mg | $950 | In-stock |
| 50mg | $1280 | In-stock |
| 100mg | $1730 | In-stock |
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| Cat. No. : | HY-16723 |
| M.Wt: | 429.35 |
| Formula: | C22H14F3NO5 |
| Purity: | >98 % |
| Solubility: | DMSO : 200 mg/mL (ultrasonic) |
Funapide (TV 45070; XEN402) is an orally active inhibitor of voltage-gated sodium channels (VGSC) in the peripheral nervous system with IC50 values ??of 84 nM and 54 nM for Nav1.5 and Nav1.7, respectively. Funapide has analgesic effects[1][2]. IC50 & Target:IC50: 601, 84, 173 and 54 nM for NaV1.2, NaV1.5, NaV1.6 and NaV1.7[1] In Vitro:Funapide is a potent state-dependent voltage-gated sodium channel (VGSC) inhibitor with IC50s of 601, 84, 173 and 54 nM for NaV1.2, NaV1.5, NaV1.6 and NaV1.7, respectively[1]. In Vivo:Funapide produces analgesia in models of hereditary erythromelalgia (IEM) and postherpetic neuropathic pain (PHN) (NaV1.7 gain-of-function mutations). In doing so, Funapide blocks Nav1.7-mediated pain associated with IEM[1][2].
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