TNP-351
CAS No. : 125991-51-7
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| Cat. No. : | HY-19095 |
| M.Wt: | 440.45 |
| Formula: | C21H24N6O5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
TNP-351 is an antifolate. TNP-351, a dihydrofolate reductase (DHFR) inhibitor, has potent antitumor activity against not only leukemia cells but also solid tumor cells in vitro and in vivo[1].
IC50 & Target: Antifolate, DHFR[1]
In Vitro: TNP-351 inhibits the proliferation of mouse L1210 leukemia cells and human CCRF-CEM lymphoblastic leukemia cells with ED50 values of 0.79 and 2.7 nM, respectively[1].
The ED50 values determined for the parent cell line CCRF-CEM, CCRFCEM R30/6 subline, CCRF-CEM R1, and CCRF-CEM R2 are 2.7, 5.8, 94 and 76 nM, respectively[1].
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