NusB-NusE interaction IN-1


CAS No. : 125966-81-6

125966-81-6
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Cat. No. : HY-123722
M.Wt: 564.61
Formula: C28H28N4O7S
Purity: >98 %
Solubility:
Introduction of 125966-81-6 :

NusB-NusE interaction IN-1 (compound 1) is a NusB-NusE protein-protein interaction inhibitor and growth inhibitor with a Bacillus subtilis IC50 of 6.1 μM.NusB-NusE interaction IN-1 inhibits growth of Gram-positive Bacillus subtilis.NusB-NusE interaction IN-1 inhibits growth of Gram-negative Escherichia coli[1]. In Vitro:NusB-NusE interaction IN-1 (compound 1) (25 μM; 15 min at 37 °C, 1 h at room temperature) potently inhibits the protein-protein interaction between Bacillus subtilis NusB and NusE with an IC50 of 6.1 μM, achieving 88% inhibition at a 25 μM concentration[1].
NusB-NusE interaction IN-1 (compound 1) (200 μM; 16 h at 37 °C) moderately inhibits the growth of Bacillus subtilis (9% inhibition) and Escherichia coli DH5α (21% inhibition) at a 200 μM concentration[1].

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