VU0155041 (sodium)
CAS No. : 1259372-69-4
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| Cat. No. : | HY-14417B |
| M.Wt: | 338.16 |
| Formula: | C14H14Cl2NNaO3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
VU0155041 sodium is a potent, selective positive allosteric modulator (PAM) of mGluR4, with EC50s of 798 nM and 693 nM for human and rat mGluR4, respectively. VU0155041 has potential for the research of Parkinson's disease (PD)[1].
In Vitro: VU0155041 (10 μM) does not affect NMDA receptor currents in striatal medium spiny neurons[1].
In Vivo: VU0155041 (31 nmol, 93 nmol; i.c.v.) reverses catalepsy induced by the dopamine D2 receptor antagonist Haloperidol (1.5 mg/kg, i.p.) in rats[1].
VU0155041 (93 nmol, 316 nmol; i.c.v.) reverses Reserpine (HY-N0480) -induced akinesia in rats[1].
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