Sparstolonin B
CAS No. : 1259330-61-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $110 | In-stock |
| 10mg | $195 | In-stock |
| 25mg | $425 | In-stock |
| 50mg | $720 | In-stock |
| 100mg | $1220 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-116213 |
| M.Wt: | 268.22 |
| Formula: | C15H8O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 10 mg/mL (ultrasonic;warming) |
Sparstolonin B acts as a selective TLR2 and TLR4 antagonist and selectively blocks TLR2- and TLR4-mediated inflammatory signaling. Sparstolonin B has anti-HIV and anticancer activities[1][2].
In Vitro: Sparstolonin B (1-20 µM; 2-4 days) inhibits cell growth and viability of neuroblastoma cells[3].
Sparstolonin B inhibits TLR ligand-induced cytokine expression in mouse macrophages. Sparstolonin B inhibits MyD88 recruitment to TLR4 and TLR2[1].
Sparstolonin B generates reactive oxygen species (ROS) in neuroblastoma cells. Sparstolonin B reduces expression of N-myc in neuroblastoma cells[3].
In Vivo: Sparstolonin B (100 μg/mouse; i.p.) suppresses LPS-provoked inflammation in mice[1].
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