TLR7/8 agonist 1
CAS No. : 1258457-59-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $143 | In-stock |
| 10mg | $231 | In-stock |
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| 50mg | $825 | In-stock |
| 100mg | $1375 | In-stock |
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| Cat. No. : | HY-103698 |
| M.Wt: | 359.47 |
| Formula: | C22H25N5 |
| Purity: | >98 % |
| Solubility: | DMSO : 11.11 mg/mL (ultrasonic;warming;heat to 60°C) |
TLR7/8 agonist 1 is a toll-like receptor (TLR7)/TLR8 dual-agonistic imidazoquinoline. IC50 & Target:TLR7/TLR8[1] In Vitro: TLR7/8 agonist 1 (Compound 5d) shows prominent immunostimulatory activities. TLR7/8 agonist 1 serves as a convenient precursor for the covalent attachment of fluorophores without significant loss of activity.TLR7/8 agonist 1 retains TLR7-agonistic activity with an EC50 of 20 nM. TLR7/8 agonist 1 is covalently coupled directly to commercially-available fluorescein isothiocyanate and rhodamine B isothiocyanate[1]. TLR7/8 agonist 1 (Compound 1) shows substantially different agonistic potencies in human TLR7 (50 nM) and TLR8 (55 nM) primary screens[2].
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