ACT-389949
CAS No. : 1258417-54-7
| Size | Price | Stock |
|---|---|---|
| 1mg | $199 | In-stock |
| 5mg | $304 | In-stock |
| 10mg | $456 | In-stock |
| 25mg | $822 | In-stock |
| 50mg | $1233 | In-stock |
| 100mg | $1850 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-124071 |
| M.Wt: | 428.39 |
| Formula: | C20H18F2N6O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 10 mg/mL (ultrasonic;adjust pH to 1 with HCl) |
ACT-389949 is a first-in-class, potent and selective and agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC50 of 3 nM for FPR2/ALX internalization into monocytes. ACT-389949 has potential for the treatment of inflammatory disorders[1][2].
IC50 & Target: (FPR2)/(ALX)[1]
In Vivo: ACT-389949 has well tolerated. Maximum concentrations are reached around 2 hours after dosing, with a mean terminal half-life of 29.3 hours[1].
Administration of ACT-389949 results in a dose-dependent, long-lasting internalization of FPR2/ALX into leukocytes[1].
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